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Enzyme Research
Reports outline enzyme research study results from New York Medical College, Medical College
October 28th, 2008
According to recent research published in the journal Nucleic Acids Research, "Among bacterial topoisomerase I enzymes, a conserved methionine residue is found at the active site next to the nucleophilic tyrosine. Substitution of this methionine residue with arginine in recombinant Yersinia pestis topoisomerase I (YTOP) was the only substitution at this position found to induce the SOS response in Escherichia coli." "Overexpression of the M326R mutant YTOP resulted in similar to 4 log loss of viability. Biochemical analysis of purified Y. pestis and E. coli mutant topoisomerase I showed that the Met to Arg substitution affected the DNA religation step of the...
Source: TB & Outbreaks Week (2008-10-28)
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