TB & Outbreaks Week
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Escherichia coli
Reports from R. Mittal et al highlight recent research in Escherichia coli
October 28th, 2008
According to recent research from the United States, "Dendritic cells (DCs) are professional APCs that direct both cellular and Immoral immune responses. Escherichia coli K1 causes meningitis in neonates; however, the interactions between this pathogen and DCs have not been previously explored." "In the present study, we observed that E. coli K1, expressing outer membrane protein A (OmpA), was able to enter, survive, and replicate inside DCs, whereas OmpA(-) E. coli was killed within a short period. Opsonization of OmpA(+) E. coli either with adult or cord serum did not affect its survival inside DCs. Exposure of DCs to live OmpA(+) E. coli K1 prevented DCs from...
Source: TB & Outbreaks Week (2008-10-28)
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