TB & Outbreaks Week
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Mumps
Research reports on mumps from A. Letortorec and colleagues provide new insights
October 28th, 2008
According to recent research from Rennes, France, "The immuno-privileged status of the testis is essential to the maintenance of its functions, and innate immunity is likely to play a key role in limiting harmful viral infections, as demonstrated in the rat. In men mumps virus infects Leydig cells and has deleterious effects on testosterone production and spermatogenesis." "The aim of this study was to test whether mumps virus infection of isolated human Leydig cells was associated with an inhibition of their innate antiviral defences. Leydig cell production of mRNA and protein for interferons (IFNs) and of three antiviral proteins-2'5' oligoadenylate synthetase...
Source: TB & Outbreaks Week (2008-10-28)
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