TB & Outbreaks Week
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Tuberculosis
New findings from W.W. Reiley and co-researchers in the area of tuberculosis described
October 28th, 2008
According to a study from the United States, "CD4(+) T cell responses to aerosol Mycobacterium tuberculosis (Mtb) infection are characterized by the relatively delayed appearance of effector T cells in the lungs. This delay in the adaptive response is likely critical in allowing the bacteria to establish persistent infection." "Because of limitations associated with the detection of low frequencies of naive T cells, it had not been possible to precisely determine when and where naive antigen-specific T cells are first activated. We have addressed this problem by using early secreted antigenic target 6 (ESAT-6)-specific transgenic CD4 T cells to monitor early T cell...
Source: TB & Outbreaks Week (2008-10-28)
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