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DNA Research
Louisiana State University details research in DNA research
October 28th, 2008
According to a study from the United States, "Histone-like proteins (such as HU, H-NS, and Fis) participate in nucleoid organization and in DNA replication, recombination, and transcription. Cold shock and anoxia upregulates a homologue of HU (Hlp) in Mycobacterium smegmatis, the nonpathogenic model of Mycobacterium tuberculosis." "We show using electrophoretic mobility shift assays that Hlp, which in addition to the HU fold has a basic C-terminal tail containing multiple PAKK and PAAK repeats, has very high affinity for DNA. The affinity of Hlp for 76 bp linear DNA is higher, K-d = 0.037 +/- 0.001 nM, compared to art Hlp variant without the C-terminal repeats, K-d =...
Source: TB & Outbreaks Week (2008-10-28)
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