TB & Outbreaks Week
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Bacillus Calmette-Guerin Vaccines
Studies from Kuwait University, Medical Department have provided new information about Bacillus calmette-guerin vaccines
November 4th, 2008
According to recent research from Kuwait, "Comparative genomics has identified several regions of difference (RDs) of Mycobacterium tuberculosis that are deleted or absent in Mycobacterium bovis BCG vaccines. To determine their relevance for diagnostic and vaccine applications, it is imperative that efficient methods are developed to test the encoded proteins for immunological reactivity." "In this study, we have used 220 synthetic peptides covering sequences of 12 open reading frames (ORFs) of RD1 and tested them as a single pool (RD1pool) with peripheral blood mononuclear cells obtained from pulmonary tuberculosis (TB) patients and M. bovis BCG-vaccinated healthy...
Source: TB & Outbreaks Week (2008-11-04)
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