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TB & Outbreaks Week

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Mumps



Reports on mumps findings from T. Kosuticgulija and co-researchers provide new insights



November 4th, 2008

"The most often used mumps vaccine strains Jeryl Lynn (JL), RIT4385, Urabe-AM9, L-Zagreb and L-3 differ in immunogenicity and reactogenicity. Previous analyses showed that JL, Urabe-AM9 and L-3 are genetically heterogeneous," scientists in Zagreb, Croatia report.

"We identified the heterogeneity of L-Zagreb throughout the entire genome. Two major variants were defined: variant A being identical to the consensus sequence of viral seeds and vaccine(s) and variant B which differs from variant A in three nucleotide positions. The difference between viral variants in L-Zagreb strain is insufficient for distinct viral strains to be defined. We demonstrated that proportion of...


Source: TB & Outbreaks Week (2008-11-04)

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