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TB & Outbreaks Week

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Mycobacteria



Reports from Colorado State University highlight recent research in mycobacteria



November 4th, 2008

According to a study from the United States, "This study was performed to examine the adaptive immune response generated by three Mycobacterium bovis bacillus Calmette-Guerin (BCG) substrains to determine if the number of genomic regions of deletion played a significant role in determining the magnitude of the immune response or affected their ability to reduce the bacterial burden following low-dose aerosol challenge with a virulent M. tuberculosis strain. BCG Connaught, Pasteur, and Sweden were chosen as representative substrains, as they possessed many, intermediate, and few regions of deletion, respectively, as a result of changes in the genome in various regions."

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Source: TB & Outbreaks Week (2008-11-04)

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