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TB & Outbreaks Week

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Plague



Researchers at State University of New York publish new data on plague



November 4th, 2008

According to recent research from the United States, "Pathogenic Yersinia species utilize a type III secretion system (T3SS) to translocate effectors called Yersinia outer proteins (Yops) into infected host cells. Previous studies demonstrated a role for effector Yops in the inhibition of caspase-1-mediated cell death and secretion of interleukin-1 beta (IL-1 beta) in naive macrophages infected with Yersinia enterocolitica."

"Naive murine macrophages were infected with a panel of different Yersinia pestis and Yersinia pseudotuberculosis strains to determine whether Yops of these species inhibit caspase-1 activation. Cell death was measured by release of lactate...


Source: TB & Outbreaks Week (2008-11-04)

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