TB & Outbreaks Week
Welcome to NewsRx!
Learn more about a six-week, no-risk free trial of TB & Outbreaks Week
We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.
Tuberculosis
Investigators at College of Medicine release new data on tuberculosis
November 4th, 2008
"Resuscitation-promoting factors (Rpfs), apparent peptidoglycan hydrolases, have been implicated in the reactivation of dormant bacteria. We previously demonstrated that deletion of rpfB impaired reactivation of Mycobacterium tuberculosis in a mouse model. Because M. tuberculosis encodes five Rpf paralogues, redundant functions among the family members might obscure rpf single-knockout phenotypes," scientists in the United States report. "A series of rpf double knockouts were therefore generated. One double mutant, Delta rpfAB, exhibited several striking phenotypes. Consistent with the proposed cell wall-modifying function of Rpfs, Delta rpfAB exhibited an altered...
Source: TB & Outbreaks Week (2008-11-04)
|
