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Aspergillosis
Reports from L.Y. Chiang and co-researchers add new data to research in aspergillosis
November 4th, 2008
According to recent research from the United States, "Invasive aspergillosis is characterized by hyphal invasion of the blood vessels, which contributes to the pathogenesis of this disease. During this angioinvasion, Aspergillus fumigatus interacts with the endothelial cell lining of the blood vessels." "We investigated the response of vascular endothelial cells to A.fumigatus infection in vitro and in mouse models of invasive pulmonary aspergillosis. Infection with hyphae, but not with conidia, stimulated endothelial cells to synthesize E-selectin, vascular cell adhesion molecule 1 (VCAM-1), interieukin 8, and tumor necrosis factor alpha (TNF-alpha) in vitro. Killed...
Source: TB & Outbreaks Week (2008-11-04)
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