TB & Outbreaks Week
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Aspergillosis
Research from A. Valloneberhard and co-researchers in the area of aspergillosis described
November 4th, 2008
"Aspergillus fumigatus is an opportunistic fungal pathogen responsible for invasive aspergillosis in immuno-compromised individuals. The inefficiency of antifungal agents and high mortality rate resulting from invasive aspergillosis remain major clinical concerns," investigators in Rehovot, Israel report. "Recently, we reported on a new family of ultrashort cationic lipopeptides active in vitro against fungi. Mode of action studies supported a membranolytic or a detergent-like effect. Here, we screened several lipopeptides in vitro for their anti-A. fumigatus activity. To investigate the therapeutic properties of the selected peptides in vivo, we challenged...
Source: TB & Outbreaks Week (2008-11-04)
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