Aspergillosis

Scientists at McGill University report research in aspergillosis

Published in TB and Outbreaks Week, November 4th, 2008

"Very little is known about the developmental stages of Aspergillus fumigatus during invasive aspergillosis. We performed real-time reverse transcription-PCR analysis on lung samples from mice with invasive pulmonary aspergillosis to determine the expression of A. fumigatus genes that are expressed at specific stages of development," scientists in Montreal, Canada report.

"In established infection, A. fumigatus exhibited mRNA expression of genes specific to developmentally competent hyphae, such as stuA. In contrast, mRNA of genes expressed by conidia and precompetent hyphae was not detected. Many genes required for mycotoxin synthesis, including aspHS, gliP, mitF, and...

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Source: TB and Outbreaks Week (2008-11-04)

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