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Life Sciences
New findings reported from Osaka University describe advances in life sciences
November 11th, 2008
According to a study from Suita, Japan, "Four genes (bamA1, bamA2, bamA3 and bamA4) encoding homologues of the gamma-butyrolactone autoregulator receptor of Streptomyces were found and cloned from Amycolatopsis mediterranei, a typical non-Streptomyces actinomycetes and a producer of rifamycin, one of the major anti-tuberculosis drugs in clinical treatment. Transcriptional analysis demonstrated that bamA1 and bamA2 are transcribed in a growth-dependent manner, while bamA3 and bamA4 are constitutively transcribed during growth." "Binding assays using H-3-labeled autoregulator analogues as ligands confirmed that all of the recombinant BamA proteins expressed in Escherichia...
Source: TB & Outbreaks Week (2008-11-11)
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