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Mycobacteria
Findings from University of Paris advance knowledge in mycobacteria
November 11th, 2008
According to a study from Paris, France, "Natural modification of the colony appearance is a phenomenon that has not been fully understood in mycobacteria. Here, we show that Mycobacterium smegmatis ATCC607 displays a low-frequency spontaneous morphological variation that correlates with the acquisition of a panel of new phenotypes, such as aggregation, biofilm formation and sliding motility." "These variants produce larger amounts of glycopeptidolipid (GPL), a cell-surface component, than did the wild-type strain. This conversion results from the transposition of two types of insertion sequences, IS 1096 and ISMsm3, into two loci. One locus is the promoter region of...
Source: TB & Outbreaks Week (2008-11-11)
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