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Parasitic Disease
Studies from S.P. Fricker et al in the area of parasitic disease described
November 11th, 2008
According to recent research from the United States, "The cysteine proteases of the trypanosomatid parasitic protozoa have been validated as targets for chemotherapy of Chagas' disease and leishmaniasis. Metal complexes of gold, platinum, iridium, palladium, rhodium and osmium have been reported to have activity against a variety of trypanosomatids, but the molecular target of these compounds has not been defined." "The activity of gold(III) and palladium(II) cyclometallated complexes, and oxorhenium(V) complexes against mammalian and parasitic cysteine proteases was investigated. All gold(III) complexes (1-6) inhibited cathepsin B with IC50 values in the range of...
Source: TB & Outbreaks Week (2008-11-11)
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