Tuberculosis
New tuberculosis research from State University of New York described
Published in TB and Outbreaks Week, November 11th, 2008
According to recent research published in the journal Tuberculosis, "A temperature sensitive mutation in the cell, division protein FtsZ was used in combination with transcriptional analysis to identify biomarkers for inhibition of septum formation. Crystallography and modeling revealed that the glycine for aspartate substitution at amino acid 210 was located in helix 8 of the protein, adjacent to the T7 synergy loop."
"To verify the molecular behavior of FtSZ(D210G), the in vitro activity and structural stability were evaluated as a function of temperature. These analyses confirmed that the FtsZ(D21OG) mutant had reduced GTPase and polymerization activity...
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