TB & Outbreaks Week
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Tuberculosis
Research reports on tuberculosis from S.P.S. Rao and colleagues provide new insights
November 11th, 2008
According to recent research published in the journal Proceedings of the National Academy of Sciences of the United States of America, "The persistence of Mycobacterium tuberculosis despite prolonged chemotherapy represents a major obstacle for the control of tuberculosis. The mechanisms used by Mtb to persist in a quiescent state are largely unknown." "Chemical genetic and genetic approaches were used here to study the physiology of hypoxic nonreplicating mycobacteria. We found that the intracellular concentration of ATP is five to six times lower in hypoxic nonreplicating Mtb cells compared with aerobic replicating bacteria, making them exquisitely sensitive to...
Source: TB & Outbreaks Week (2008-11-11)
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