TB & Outbreaks Week
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Tuberculosis
Studies from University of Illinois in the area of tuberculosis described
November 11th, 2008
"The ability to construct defined deletions of Mycobacterium tuberculosis has allowed many genes involved in virulence to be identified. Deletion of nutritional genes leads to varying levels of attenuation, presumably reflecting the need for a particular molecule, and the availability (or tack) of that molecule in vivo," investigators in the United States report. "We have previously shown that M. tuberculosis mutants lacking either the trpD or ino1 gene are highly attenuated in mouse models of infection, but can grow when supplemented with tryptophan or inositol, respectively. In this paper we have constructed a double Delta trpD Delta ino1 mutant, and show that this is...
Source: TB & Outbreaks Week (2008-11-11)
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