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Tuberculosis
Study data from G.S. Hotter and co-authors update knowledge of tuberculosis
November 11th, 2008
According to a study from New Zealand, "Mycobacterium bovis and Mycobacterium tuberculosis possess four glutamine synthetase homologues, two of which, glnA1 and glnA2, are required for virulence and are Located on the bacterial, chromosome on either side of glutamine synthetase adenylyltransferase (glnE). While glnA1 is encoded on the complementary strand, glnA2 is located 48 bp upstream from glnE, raising the possibility that glnA2 and glnE may be co-transcribed." "However, previous studies in M. bovis and M. tuberculosis have painted a contradictory picture of the (co)transcriptional, status of glnA2 and glnE. Given the importance of the genes at the glnA1-glnE-glnA2...
Source: TB & Outbreaks Week (2008-11-11)
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