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Plague Vaccines
New data from University of Idaho illuminate research in plague vaccines
November 11th, 2008
Fresh data on plague are presented in the report 'Lipid A mimetics are potent adjuvants for an intranasal pneumonic plague vaccine.' "An effective intranasal (i.n.) vaccine against pneumonic plague was developed. The formulation employed two synthetic lipid A mimetics as adjuvant combined with Yersinia pestis-derived V-and F1-protective antigens," scientists in the United States report. "The two nontoxic lipid A mimetics, classed as amino-alkyl glucosaminide 4-phosphates (AGPs) are potent ligands for the Toll-like receptor (TLR) 4. Using a murine (BALB/c) pneumonic plague model, we showed a single i.n. application of the vaccine provided 63% protection within 21 days...
Source: TB & Outbreaks Week (2008-11-11)
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