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Tuberculosis
Researchers from University of California discuss findings in tuberculosis
November 11th, 2008
New research, 'Protein tyrosine phosphatase PtpA is not required for Mycobacterium tuberculosis growth in mice,' is the subject of a report. "Mycobacterium tuberculosis (Mtb) alters the host response to infection by secreting protein factors. Mtb produces two secreted protein tyrosine phosphatases, PtpA and PtpB, which are thought to interfere with host signaling," scientists writing in the journal FEMS Microbiology Letters report. "Deletion of ptpA or ptpB attenuates bacterial growth in activated macrophages. To address the in vivo function of PtpA, we generated a genetic deletion mutant, DeltaptpA. The mutant was not defective when grown in vitro,...
Source: TB & Outbreaks Week (2008-11-11)
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