TB & Outbreaks Week
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Tuberculosis
New findings from V.R. Winrow and co-authors describe advances in tuberculosis
November 18th, 2008
"Mycobacterium tuberculosis produces two homologous chaperonin (Cpn)60 proteins, Cpn60.1 and Cpn60.2 (Hsp65). Both proteins stimulate human and murine monocyte cytokine synthesis but, unlike Cpn60 proteins from other microbial species, fail to stimulate the breakdown of cultured murine bone," scientists writing in the journal Cellular Microbiology report. "Here, we have examined the mechanism of action of these proteins on bone remodelling and osteoclastogenesis, induced in vitro in murine calvarial explants and the murine monocyte cell line RAW264.7. Additionally, we have determined their effect on bone remodelling in vivo in an animal model of arthritis....
Source: TB & Outbreaks Week (2008-11-18)
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