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Tuberculosis
Research from University of Illinois in the area of tuberculosis published
November 18th, 2008
According to recent research from the United States, "Existing 14, 15 and 16-membered macrolide antibiotics, white effective for other bacterial, infections, including some mycobacteria, have not demonstrated significant. efficacy in tuberculosis. Therefore an attempt was made to optimize this class for activity against Mycobacterium tuberculosis through semisyntheses and bioassay." "Approximately 300 macrolides were synthesized and screened for anti-TB activity. Structural modifications on erythromycin were carried out at positions 3, 6, 9, 11, and 12 of the 14-membered lactone ring; as well as at position 4'' of cladinose and position 2' of desosamine. In general, the...
Source: TB & Outbreaks Week (2008-11-18)
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