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Escherichia Coli
Study findings from University of London, Imperial College provide new insights into Escherichia coli
November 25th, 2008
According to recent research from London, the United Kingdom, "Enterohemorrhagic Escherichia coli (EHEC) O157: H7 is an important human pathogen that colonizes the gut mucosa via attaching and effacing (A/E) lesions; A/E lesion formation in vivo and ex vivo is dependent on the type III secretion system (T3SS) effector Tir. Infection of cultured cells by EHEC leads to induction of localized actin polymerization, which is dependent on Tir and a second T3SS effector protein, TccP, also known as EspF(U)." "Recently, cortactin was shown to bind both the N terminus of Tir and TccP via its SH3 domain and to play a role in EHEC-triggered actin polymerization in vitro. In this...
Source: TB & Outbreaks Week (2008-11-25)
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