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Hantavirus
New hantavirus study findings reported from State University of New York
November 25th, 2008
According to a study from the United States, "Pathogenic hantaviruses replicate within human endothelial cells and cause two diseases, hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome. In order to replicate in endothelial cells pathogenic hantaviruses inhibit the early induction of beta interferon (IFN-beta)." "Expression of the cytoplasmic tail of the pathogenic NY-1 hantavirus Gn protein is sufficient to inhibit RIG-I- and TBK1-directed IFN responses. The formation of TBK1-TRAF3 complexes directs IRF-3 phosphorylation, and both IRF-3 and NF-kappa B activation are required for transcription from the IFN-beta promoter. Here we report that the NY-1...
Source: TB & Outbreaks Week (2008-11-25)
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