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Infectious Disease
Research results from University of Cape Town update understanding of infectious disease
November 25th, 2008
According to recent research from Cape Town, South Africa, "To determine the immunological role played by interleukin (IL)-12 family members in Trypanosoma congolense infection, IL-12p35(-/-), IL-12p40(-/-), and IL-12p35(/-/-)p40(-/-) mice were used. While the latter 2 strains lack all IL-12 homologues, IL-12p35m(-/-) ice still produce IL-12p80 homodimers and IL-23." "Compared with wild-type mice, all infected IL-12-deficient mouse strains showed prolonged survival, whereas parasitemia levels were unaltered. Interferon (IFN)-gamma production in IL-12-deficient mice was strikingly reduced during the acute and chronic stages of infection, coinciding with significantly...
Source: TB & Outbreaks Week (2008-11-25)
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