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Influenza
Study results from J. Stevens and colleagues in the area of influenza published
November 25th, 2008
"Adaptation of avian influenza viruses for replication and transmission in the human host is believed to require mutations in the hemagglutinin glycoprotein (HA) which enable binding to human alpha 2-6 sialosides and concomitant reduction in affinity for avian alpha 2-3 linked sialosides. Here, we show by glycan microarray analyses that the two mutations responsible for such specificity changes in 1957 H2N2 and 1968 H3N2 pandemic viruses, when inserted into recombinant HAs or intact viruses of some recent avian H5N1 isolates (clade 2.2), impart such attributes," scientists in the United States report. "This propensity to adapt to human receptors is primarily dependent...
Source: TB & Outbreaks Week (2008-11-25)
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