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Legionnaire Disease
Research results from Tel-Aviv University update knowledge of legionnaire disease
November 25th, 2008
"Legionella pneumophila is an intracellular pathogen that has been shown to utilize the Icm/Dot type IV secretion system for pathogenesis. This system was shown to be composed of Icm/Dot complex components, accessory proteins, and a large number of translocated substrates," researchers in Tel Aviv, Israel report. "In this study, comparison of the icmQ regulatory regions from many Legionella species revealed a conserved regulatory sequence that includes the icmQ -10 promoter element. Mutagenesis of this conserved regulatory element indicated that each of the nucleotides in it affects the level of expression of the icmQ gene but not in a uniform fashion. A genomic...
Source: TB & Outbreaks Week (2008-11-25)
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