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TB & Outbreaks Week

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Plague



Studies from Y.P. Han and co-authors have provided new information about plague



November 25th, 2008

"The catalase or catalase-peroxidase activity commonly exists in many pathogens and plays an important role in resisting the oxidative burst of phagocytes helping the pathogen persistently colonize in the host. Yersinia pestis is a facultative pathogen and the causative agent of plague," researchers in Beijing, People's Republic of China report.

"KatY has been identified as a thermosensing antigen with modest catalase activity in this pathogen. Here Y. pestis KatA and KatY were experimentally confirmed as a monofunctional catalase and bifunctional catalase-peroxidase, respectively. Their expression induced by H2O2 was proven to be mediated by the oxidative regulator,...


Source: TB & Outbreaks Week (2008-11-25)

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