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Tuberculosis
Study data from Brigham and Women's Hospital update understanding of tuberculosis
November 25th, 2008
"Macrophages infected with attenuated Mycobacterium tuberculosis strain H37Ra become apoptotic, which limits bacterial replication and facilitates antigen presentation," scientists in the United States report. "Here we demonstrate that cells infected with H37Ra became apoptotic after the formation of an apoptotic envelope on their surface was complete. This process required exposure of phosphatidylserine on the cell surface, followed by deposition of the phospholipid-binding protein annexin-1 and then transglutaminase-mediated crosslinking of annexin-1 through its amino-terminal domain," wrote H.X. Gan and colleagues, Brigham and Women's Hospital. ...
Source: TB & Outbreaks Week (2008-11-25)
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