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Apoptosis
New apoptosis study results from P. Misra et al described
November 25th, 2008
"The aim of this study was to resolve the putative pathway responsible for death induced by peganine hydrochloride dihydrate isolated from Peganum harmala seeds at cellular, structural and molecular level in Leishmania donovani, a causative agent of fatal visceral leishmaniasis. The mode of action was assessed using various biochemical approaches including phosphatidylserine exposure, estimation of mitochondrial transmembrane potential and in situ dUTP nick end labelling staining of nicked DNA in the parasite," researchers in Lucknow, India report. "Molecular modelling and molecular dynamics studies were conducted with DNA topoisomerase I to identify the target of...
Source: TB & Outbreaks Week (2008-11-25)
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