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Leishmaniasis
New leishmaniasis research from Federal University discussed
December 2nd, 2008
According to recent research published in the journal International Immunopharmacology, "Tumor necrosis factor-alpha (TNF-alpha) is known to have numerous biological properties relating to inflammation. This cytokine participates in the tissue damage of chronic inflammatory, autoimmune and infectious diseases." "Pentoxifylline is a methylxanthine that inhibits phosphodiesterase IV, which inhibits the degradation of the cAMP and prostanoids. The increased intracellular concentration of the cAMP leads to a negative regulation of NF-kappa B and NF-AT transcription factors and suppresses TNF-alpha production. This review describes studies that support evidences that...
Source: TB & Outbreaks Week (2008-12-02)
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