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Protease
Scientists at University of Queensland detail research in protease
December 2nd, 2008
"West Nile virus (WNV) has spread rapidly around the globe, efficiently crossing species from migrating birds into humans and other mammals. The viral protease NS2B-NS3 is important for WNV replication and recognizes dibasic substrate sequences common to other flaviviral proteases but different from most mammalian proteases," scientists writing in the Journal of Medicinal Chemistry report. "Potent inhibitors of WNV protease with antiviral activity have been elusive to date. We report the smallest and most potent inhibitors known for this enzyme, cationic tripeptides with nonpeptidic caps at the N-terminus and aldehyde at the C-terminus," wrote M.J. Stoermer and...
Source: TB & Outbreaks Week (2008-12-02)
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