TB & Outbreaks Week
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Proteomics
Reports summarize proteomics study results from E.A. Fradinger and co-researchers
December 2nd, 2008
"Alzheimer's disease (AD) is an age-related disorder that threatens to become an epidemic as the world population ages. Neurotoxic oligomers of A beta 42 are believed to be the main cause of AD; therefore, disruption of A beta oligomerization is a promising approach for developing therapeutics for AD," scientists in the United States report. "Formation of A beta 42 oligomers is mediated by intermolecular interactions in which the C terminus plays a central role. We hypothesized that peptides derived from the C terminus of A beta 42 may get incorporated into oligomers of A beta 42, disrupt their structure, and thereby inhibit their toxicity. We tested this hypothesis...
Source: TB & Outbreaks Week (2008-12-02)
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