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Tuberculosis Vaccines
Reports summarize tuberculosis vaccines study results from St. Louis University, Center for Vaccine Development
December 2nd, 2008
Data detailed in 'A new recombinant bacille Calmette-Guérin vaccine safely induces significantly enhanced tuberculosis-specific immunity in human volunteers' have been presented. "One strategy for improving anti-tuberculosis (TB) vaccination involves the use of recombinant bacille Calmette-Guérin (rBCG) overexpressing protective TB antigens. rBCG30, which overexpresses the Mycobacterium tuberculosis secreted antigen Ag85b, was the first rBCG shown to induce significantly greater protection against TB in animals than parental BCG. We report here the first double-blind phase 1 trial of rBCG30 in 35 adults randomized to receive either rBCG30 or parental Tice BCG intradermally,"...
Source: TB & Outbreaks Week (2008-12-02)
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