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Drug Resistance
New findings reported from E. Castanysmunoz and co-authors describe advances in drug resistance
December 2nd, 2008
"Leishmaniasis treatment is hampered by the increased appearance of treatment failure. ATP-binding cassette (ABC) transporters are usually involved in drug resistance both in tumor cells and in microorganisms," investigators in Granada, Spain report. "Here we report the characterization of an ABCG-like transporter, LiABCG6, localized mainly at the plasma membrane in Leishmania protozoan parasites. When overexpressed, this half-transporter confers significant resistance to the leishmanicidal agents miltefosine and sitamaquine. This resistance phenotype is mediated by a reduction in intracellular drug accumulation. LiABCG6 also reduces the accumulation of short-chain...
Source: TB & Outbreaks Week (2008-12-02)
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