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Enzyme Research
Study data from University of Wisconsin provide new insights into enzyme research
December 9th, 2008
According to a study from the United States, "Perosamine (4-amino-4,6-dideoxy-D-mannose), or its N-acetylated form, is one of several dideoxy sugars found in the O-antigens of such infamous Gram-negative bacteria as Vibrio cholerae 01 and Escherichia coli O157:H7. It is added to the bacterial O-antigen via a nucleotide-linked version, namely GDP-perosamine." "Three enzymes are required for the biosynthesis of GDP-perosamine starting from mannose 1-phosphate. The focus of this investigation is GDP-perosamine synthase from Caulobacter crescentus, which catalyzes the final step in GDP-perosamine synthesis, the conversion of GDP-4-keto-6-deoxymannose to GDP-perosamine. The...
Source: TB & Outbreaks Week (2008-12-09)
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