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Tuberculosis
Reports from University of Oxford highlight recent research in tuberculosis
December 9th, 2008
According to recent research from Oxford, the United Kingdom, "Boosting bacillus Calmette-Guerin (BCG)-primed mice with a recombinant adenovirus expressing Mycobacterium tuberculosis Ag 85A by different administration routes has very different effects on protection against aerosol challenge with M. tuberculosis. Mice boosted intradermally make very strong splenic CD4 and CD8 Th1 cytokine responses to Ag 85A, but show no change in lung mycobacterial burden over BCG primed animals." "In contrast, intranasally boosted mice show greatly reduced mycobacterial burden and make a much weaker splenic response but a very strong lung CD4 and CD8 response to Ag 85A and an increased...
Source: TB & Outbreaks Week (2008-12-09)
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