TB & Outbreaks Week
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Tuberculosis
Reports outline tuberculosis study findings from L.Y. Qiu and colleagues
December 9th, 2008
"The immune mechanisms by which early host-mycobacterium interaction leads to the development of severe tuberculosis (TB) remain poorly characterized in humans," scientists writing in the Journal of Infectious Diseases report. "Here, we demonstrate that severe TB in juvenile rhesus monkeys down-regulated many genes in the blood but up-regulated selected genes constituting gene networks of Th17 and Th1 responses, T cell activation and migration, and inflammation and chemoattractants in the pulmonary and lymphoid compartments. Overexpression (450-2740-fold) of 13 genes encoding inflammatory cytokines and receptors (IL-22, CCL27, MIP-1 alpha, IP-10, CCR4, CCR5, and...
Source: TB & Outbreaks Week (2008-12-09)
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