TB & Outbreaks Week
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Tuberculosis
Reports summarize tuberculosis study results from R.M. Nepal and co-researchers
December 9th, 2008
"Antigen presentation by class II MHC molecules in the uninfected host is a multi-step process involving key functions provided by specific cathepsins (Cat) and the peptide editor DM. Herein, we examined the requirement for each of these components in mice to control a low-dose aerosol infection with Mycobacterium tuberculosis (MTB)," investigators in the United States report. "Mice lacking Cat B, -L, or -S were similar to wild-type in their ability to control the growth and dissemination of MTB. In contrast, DM-/- mice failed to limit MTB growth and showed similar to 100-fold higher bacterial burden in the lung and spleen (5-6 weeks postinfection) as compared with...
Source: TB & Outbreaks Week (2008-12-09)
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