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Tuberculosis
Researchers from Laval University publish new studies and findings in the area of tuberculosis
December 9th, 2008
According to a study from Canada, "The survival of Mycobacterium tuberculosis requires detoxification of host center dot NO. Oxygenated Mycobacterium tuberculosis truncated hemoglobin N catalyzes the rapid oxidation of nitric oxide to innocuous nitrate with a second-order rate constant (k'NOD approximate to 745 x 10(6) M(-1 center dot)s(-1)), which is similar to 15-fold faster than the reaction of horse heart myoglobin." "We ask what aspects of structure and/or dynamics give rise to this enhanced reactivity. A first step is to expose what controls ligand/substrate binding to the heme. We present evidence that the main barrier to ligand binding to deoxy-truncated...
Source: TB & Outbreaks Week (2008-12-09)
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