TB & Outbreaks Week
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Tuberculosis
Study data from A.M. Gallegos and colleagues update understanding of tuberculosis
December 9th, 2008
"Mycobacterium tuberculosis infection induces complex CD4 T cell responses that include T helper type 1 (Th1) cells and regulatory T cells. Although Th1 cells control infection, they are unable to fully eliminate M. tuberculosis, suggesting that Th1-mediated immunity is restrained from its full sterilizing potential," scientists in the United States report. "Investigation into T cell-mediated defense is hindered by difficulties in expanding M. tuberculosis-specifi c T cells. To circumvent this problem, we cloned CD4(+) T cells from M. tuberculosis -infected B6 mice and generated transgenic mice expressing a T cell receptor specific for the immunodominant antigen early...
Source: TB & Outbreaks Week (2008-12-09)
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