TB & Outbreaks Week
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Vector-Borne and Zoonotic Disease
Studies from University of Wisconsin in the area of vector-borne and zoonotic disease published
December 9th, 2008
According to a study from the United States, "In addition to modulating blood meal digestion and protecting the midgut epithelial cells from mechanical and chemical damage, a biological function attributed to the mosquito type I peritrophic matrix (PM) is preventing or reducing pathogen invasion, especially from Plasmodium spp. Previously, we demonstrated that chitin is an essential component of the PM and is synthesized de novo in response to blood feeding in Aedes aegypti." "Therefore, knocking down chitin synthase expression by RNA interference severely disrupts formation of the PM. Utilizing this artificial manipulation, we determined that the absence of the PM has...
Source: TB & Outbreaks Week (2008-12-09)
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