TB & Outbreaks Week
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Influenza
New influenza research has been reported by F. Tarendeau et al
December 16th, 2008
"Understanding how avian influenza viruses adapt to human hosts is critical for the monitoring and prevention of future pandemics. Host specificity is determined by multiple sites in different viral proteins, and mutation of only a limited number of these sites can lead to inter-species transmission," scientists in Grenoble, France report. "Several of these sites have been identified in the viral polymerase, the best characterised being position 627 in the PB2 subunit. Efficient viral replication at the relatively low temperature of the human respiratory tract requires lysine 627 rather than the glutamic acid variant found systematically in avian viruses. However, the...
Source: TB & Outbreaks Week (2008-12-16)
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