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TB & Outbreaks Week

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Life Sciences



Study results from D. Chandra and colleagues broaden understanding of life sciences



December 16th, 2008

"The failure of Leishmania, an intracellular pathogen, to stimulate a pro-inflammatory response following entry into macrophages has been well reported. This occurs in spite of the fact that ligands for the toll-like receptors (TLR) have been recently shown on the parasite surface and their role in disease protection well documented," researchers in Lucknow, India report.

"The outcome of infection in leishmaniasis is determined by the Th1 versus Th2 nature of the effector response and the generation of IL-12 and IL-10 by the infected macrophages is important for this decision. We evaluated the effect of L. donovani infection of monocytes (cell line THP-1, and monocytes...


Source: TB & Outbreaks Week (2008-12-16)

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