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Plague
Reports on cell biology findings from University of Lodz provide new insights
December 16th, 2008
"Polyamidoamino (PAMAM) dendrimer of generation 3.5 (G3.5) specific interactions with rat liver mitochondria were studied. Selected parameters of mitochondria (transmembrane potential and uptake of Ca2+ ions) were investigated after the exposure to G3.5 used at the concentration of 10, 30 and 50 mc M and Ca2+ ions used at 1 mM," scientists writing in the journal Mitochondrion report. "The times of preincubation of isolated liver mitochondria, with dendrimer were 5, 15 and 30 min at room temperature. The mitochondrial membrane potential was monitored spectrofluorimetrically by fluorescence quenching of Rhodamine 123 (Rh 123). The changes in calcium homeostasis...
Source: TB & Outbreaks Week (2008-12-16)
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