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Clinical Infectious Diseases
Reports outline clinical infectious diseases study results from University of Washington
December 23rd, 2008
According to recent research published in the journal Clinical Infectious Diseases, "When investigators hypothesize that experimental interventions provide advantages other than improved effectiveness, they can use noninferiority (NI) trials to determine whether one can rule out the possibility that those interventions have unacceptably worse effectiveness than the standard ''active control'' regimen. To conduct valid NI trials, there must be evidence from historical studies that provides reliable, reproducible, and precise estimates of the effect of the active control, compared with that of placebo, on the specific outcomes investigators plan to use in the NI trial; this effect...
Source: TB & Outbreaks Week (2008-12-23)
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