TB & Outbreaks Week
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Escherichia coli
Study data from R. Maruvada et al provide new insights into Escherichia coli
December 23rd, 2008
According to a study from the United States, "Our inability to develop new therapeutic strategies to prevent meningitis due to Escherichia coli K1 is attributed to our incomplete understanding of the pathophysiology of the disease. Previously, we demonstrated that outer membrane protein A of E. coli interacts with a gp96 homologue, Ec-gp96, on human brain microvascular endothelial cells (HBMEC) for invasion." "However, signalling events mediated by Ec-gp96 that allow internalization of E. coli are incompletely understood. Here, we demonstrate that signal transducer and activator of transcription 3 (Stat3) activation and its interaction with Ec-gp96 were critical for E....
Source: TB & Outbreaks Week (2008-12-23)
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