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Meningococcal
Researchers' work from Uppsala University, Biomed Center focuses on meningococcal
December 23rd, 2008
"Neisseria meningitidis is a leading cause of meningitis and septicemia worldwide, with a rapid onset of disease and a high morbidity and mortality. NhhA is a meningococcal outer membrane protein included in the family of trimeric autotransporter adhesins," scientists writing in the journal Infection and Immunity report. "The protein binds to the extracellular matrix proteins heparan sulfate and laminin and facilitates attachment to host epithelial cells. In this study, we show that NhhA is essential for bacterial colonization of the nasopharyngeal mucosa in a murine model of meningococcal disease. Successful colonization depends on bacterial attachment but also...
Source: TB & Outbreaks Week (2008-12-23)
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